课题组详细信息请查看https://dmpmlab.github.io/

主持项目：

1. 基于DNA甲基化交互网络的癌症hallmark挖掘及其在癌症转移biomarker筛选中的应用，国家自然科学基金 (61602201), 2017.1-2019.12, 20万，主持。

2. 基于DNA甲基化交互网络的癌症hallmark挖掘及其在癌症预后中的应用研究，湖北省自然科学基金 (2016CFB139), 2016.1-2017.12, 5万，主持。

3.基于GeneRank的乳腺癌亚型精准医疗(09002021122),校自主科研基金，2018.1-2020.12, 30万，主持。

以主要作者发表的论文：

1.Xionghui Zhou, Haizi Zheng, Hailu Fu, Kelsey L. Dillehay McKillip, Susan M. Pinney, Yaping Liu. CRAG: de novo characterization of cell-free DNA fragmentation hotspots in plasma whole-genome sequencing. Genome Medicine. 2022 Dec 8;14(1):138. doi: 10.1186/s13073-022-01141-8. (SCI, IF= 15.266)

2.Ze-Jia Cui#,Min Gao#,Yuan Quan,Bo-Min Lv,Xin-Yu Tong,Teng-Fei Dai, Xiong-Hui Zhou* and Hong-Yu Zhang*. Systems Pharmacology-Based Precision Therapy and Drug Combination Discovery for Breast Cancer. Cancers 2021, 13(14), 3586; https://doi.org/10.3390/cancers13143586. (SCI, IF=6.575)

3. He-Gang Chen, Xiong-Hui Zhou*. MNBDR: A Module Network Based Method for Drug Repositioning. Genes. 2021; 12(1): 25. (SCI, IF=3.759)

4. Lu Bo, Xiong-Hui Zhou*. Ensemble Classifier based on gene synergistic network improves breast cancer outcome prediction. IEEE International Conference on Bioinformatics and Biomedicine (BIBM). 2019; 207-210. (CCF B类会议)

5. Xiong-Hui Zhou, Xin-Yi Chu, Gang Xue, Jiang-Hui Xiong, Hong-Yu Zhang*. Identifying cancer prognostic modules by module network analysis. Bmc Bioinformatics 20 2019,20:85. (SCI, IF=2.213, CCF C类期刊)

6. Ze-Jia Cui, Xiong-Hui Zhou*, Hong-Yu Zhang*. DNA Methylation Module Network-Based Prognosis and Molecular Typing of Cancer. Genes. 2019; 10(8): 571. (SCI, IF=3.759)

7. Jia-Nuo Li#, Rui Zhong#, and Xiong-Hui Zhou*. Prediction of bone metastasis in breast cancer based on minimal driver gene set in gene dependency network. Genes. 2019; 10(6): 466. (SCI, IF=3.759)

8. Gao Yi-Cheng, Xiong-Hui Zhou* and Wen Zhang*. An ensemble strategy to predict prognosis in ovarian cancer based on gene modules. Frontiers in genetics. 2019; 10:366. (SCI, IF=4.151)

9. Ling-Hao Yu, Qin-Wei Huang, Xiong-Hui Zhou*. Identification of Cancer Hallmarks Based on the Gene Co-expression Networks of Seven Cancers. Frontiers in Genetics 2019,10: https://doi.org/10.3389/fgene.2019.00099.(SCI, IF=4.151)

10. Wei-Lin Hu, Xiong-Hui Zhou*. Identification of prognostic signature in cancer based on DNA methylation interaction network. Bmc Medical Genomics, 2017, 10(4):63. (SCI, IF=3.32)

11. Xin-Yi Chu, Ling-Han Jiang , Xiong-Hui Zhou*, Ze-Jia Cui and Hong-Yu Zhang. Evolutionary Origins of Cancer Driver Genes and Implications for Cancer Prognosis. Genes, 2017,8(7). (SCI, IF=3.19)

12. Jianyong Wang, Lingling Chen, Xiong-Hui Zhou*. Identifying prognostic signature in ovarian cancer using DirGenerank. Oncotarget, 2017,doi: 10.18632/oncotarget.18189. (SCI, IF=5.168)

13. Xiwen Xu#, Xiong-Hui Zhou#, Ruiru Wang, Wenlei Peng, Yue An, Lingling Chen*. (2016) Functional analysis of long intergenic non-coding RNAs in phosphate starved rice using competing endogenous RNA network, Scientific Reports 6, 2016, doi: 10.1038/srep20715. (SCI, IF=4.259)

14. Xionghui Zhou,Juan Liu. Inferring gene dependency network specific to phenotypic alteration based on gene expression data and clinical information of breast cancer. PLoS ONE 9(3): e92023. (SCI, IF=3.573)

15. Xionghui Zhou, Juan Liu. A computational model to predict bone metastasis in breast cancer by integrating the dysregulated pathways. BMC Cancer 2014, 14:618. (SCI, IF=3.36)

16. Xionghui Zhou, Juan Liu, Wei Wang. Construction and investigation of breast-cancer-specific ceRNA network based on the mRNA and miRNA expression data. IET systems biology 8(3):pp.96-103. (SCI, IF=1.535, 期刊热点论文)

17. Xionghui Zhou, Juan Liu, Xinhuo Ye, Wei Wang, Jianghui Xiong. Ensemble classifier based on context specific miRNA regulation modules: a new method for cancer outcome prediction. BMC Bioinformatics, 14(Suppl 12):S6. (SCI, IF=3.02, CCF C类期刊)  

18. Xionghui Zhou, Juan Liu, Jianghui Xiong. Predicting distant metastasis in breast cancer using ensemble classifier based on context specific miRNA regulation modules, 2012 IEEE International Conference on Bioinformatics and Biomedicine (BIBM). pp. 1-6. (CCF B类会议，Regular paper).

19. Xionghui Zhou, Juan Liu, Changning Liu, Rayner, S., Fengji Liang, Jingfang Ju, Yinghui Li, Shanguang Chen, Jianghui Xiong. (2011) Context-Specific miRNA Regulation Network Predicts Cancer Prognosis. IEEE international conference on system biology (ISB), 2011, pp. 225-243 (EI).