报告题目：Decoding the Transcriptome of Behavior:from Yeast to Human Brain

报告人：王光中 博士

报告时间：2015年11月5日（周四）14:30

报告地点：逸夫楼C座314会议室

摘要： Behavior isthe result of adaptation to the environment of each species, ranging form yeastto human. The development of systems biology and high-throughput sequencingprovides us the opportunity to investigate the mechanisms of behavior at thegenomic level. There will be two topicscovered in this talk. First, through the analysis of circadian next-generationsequencing data and metabolic cycling data, I will describe the important roleof controlling energetic cost in the rhythmic behavior of gene expression. Thesecond focus is identifying genes that are correlated with resting state brainactivity through the analysis of both human transcriptome and fMRI datasets. Asthe molecular basis for functional brain activity is not clear, theidentification of these genes could potentially bridge the gap betweenmolecular and functional brain activity and have implications for the molecularmechanisms of autism spectrum disorder. These studies demonstrate thepower of large-scale datasets and systems biology approaches in understandingimportant biological questions.

报告人简介：王光中博士，2006年获得山东理工老员工命科学学士，2010年获得德国杜塞尔多夫老员工物信息学博士，现在为美国西南医学中心博士后。主要研究兴趣在用生物信息学和系统生物学方法解析行为以及大脑的基因组学设计原理。