报告题目：What Hi-C can tell us about chromatin organization and transcription regulation?

报告人： Dr. Zhaohui(Steve) Qin（秦朝晖）

报告时间：2016年12月25日（周五）9:50

报告地点：逸夫楼C座314会议室

摘要：

One of the new sequencing technique is the so called Hi-C(High-throughput Chromosome Conformation Capture). It aims to catch the chromatin structure by observing spatial proximal DNA sequence ligation through pair-end sequencing. The resultant data can be represented as a 2-D matrix with entries (i,j) giving number of ligations observed between position i and j on the genome. HiC data is now available in a lot of model organisms including human, mouse, fly and yeast. The most significant global feature in human and mouse HiC interaction is the plaid pattern, which lead to existence of compartment. There are a lot of unexplained patterns and the causal connection between HiC data and genome regulation is still to be explored.

报告人简介：

Dr. Qin’s research is in the areas of statistical genetics, genomics and bioinformatics. Motivated by scientific needs in these area and new technologies, he is undertaking both methodological and collaborative research. A major focus of his research is on developing and evaluating model-based methods to analyze genetics and genomics data, in particular, next generation sequencing data, and on developing software so that the methods can be easily adopted by the research community.